EDMOND HALLEY, 1656-1742

Dmd058883 1656..1662

The clinical development of fedratinib, a Janus kinase (JAK2) inhibitor, was terminated after reports of Wernicke’s encephalopathy in myelofibrosis patients. Since Wernicke’s encephalopathy is induced by thiamine deficiency, investigations were conducted to probe possible mechanisms through which fedratinib may lead to a thiamine-deficient state. In vitro studies indicate that fedratinib potent...

Brian Edmond McConnell

of 48, of Dr. Brian McConnell, one of Bristol's best known and respected practitioner5, I He will be sadly missed by his very wide circle of friends and acquaintances, not oflb in the medical profession but in the broader social world beyond it. A personal friendship which was to last for over twenty years began during the v^f in a disused Cornish sea-side boarding house where, as fellow office...

Survival analysis in joint replacement surgery.

After the widespread introduction of joint replacement surgery the early reports of outcome described success in terms of relief of pain, restoration of movement and the ability to return to normal activities. These were subsequently refined to include some assessment of the longevity of the implant and many reports now describe excellent success rates over long periods of time. The pioneering ...

Éditorial: Edmond Bianco (1932-2005)

Underpinnings of Medical Ethics Edmond

emeritus professor of medicine and former head of medical genetics at The Johns Hopkins School of Medicine; a retired research biochemist in the Laboratory of Cellular and Molecular Biology, National Institute on Aging; and a psychiatrist in private practice who is also an assistant professor of psychiatry at Johns Hopkins. Their background is therefore medical rather than philosophical, and th...